Article
Allelic loss at chromosome 13q12-q13 is associated with poor prognosis in familial and sporadic breast cancer.
British journal of cancer - 1 Nov 1996
van den Berg J, Johannsson O, Håkansson S, Olsson H, Borg A
Abstract excerpt
Loss of heterozygosity (LOH) was analysed in 84 primary tumours from sporadic, familial and hereditary breast cancer using five microsatellite markers spanning the chromosomal region 13q12-q13 which harbours the BRCA2 breast cancer susceptibility gene, and using one other marker located within th...
Topics
- Adult
- Aged
- Aged, 80 and over
- Alleles
- BRCA2 Protein
- Breast Neoplasms
- Cell Division
- Chromosomes, Human, Pair 13
- DNA, Neoplasm
- DNA, Satellite
- Female
- Gene Deletion
- Humans
- Middle Aged
- Neoplasm Proteins
- Polymerase Chain Reaction
- Prognosis
- S Phase