Article
Identification of the breast cancer susceptibility gene BRCA2.
Nature - 1 Jan 2000
Wooster R, Bignell G, Lancaster J, Swift S, Seal S, Mangion J, Collins N, Gregory S, Gumbs C, Micklem G
Abstract excerpt
In Western Europe and the United States approximately 1 in 12 women develop breast cancer. A small proportion of breast cancer cases, in particular those arising at a young age, are attributable to a highly penetrant, autosomal dominant predisposition to the disease. The breast cancer susceptibil...
Topics
- Amino Acid Sequence
- BRCA2 Protein
- Base Sequence
- Breast Neoplasms
- Breast Neoplasms, Male
- Chromosome Mapping
- Chromosomes, Artificial, Yeast
- Chromosomes, Human, Pair 13
- DNA, Neoplasm
- Female
- Frameshift Mutation
- Genetic Predisposition to Disease