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Article

Loss of heterozygosity at 13q13 and 14q32 predicts BRCA2 inactivation in luminal breast carcinomas.

International journal of cancer - 15 Dec 2013

Pécuchet Nicolas, Popova Tatiana, Manié Elodie, Lucchesi Carlo, Battistella Aude, Vincent-Salomon Anne, Caux-Moncoutier Virginie, Bollet Marc, Sigal-Zafrani Brigitte, Sastre-Garau Xavier, Stoppa-Lyonnet Dominique, Stern Marc-Henri

Abstract excerpt

BRCA2 is the major high-penetrance predisposition gene for luminal (estrogen receptor [ER] positive) breast cancers. However, many BRCA2 mutant carriers lack family history of breast/ovarian cancers and do not benefit from genetic testing. Specific genomic features associated with BRCA2 inactivation in tumors could help identify patients for whom a genetic test for BRCA2 may be proposed. A series of ER-positive...

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Identifiers

PMID: 23754601
DOI: 10.1002/ijc.28315

Genes

BRCA2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Loss of heterozygosity at 13q13 and 14q32 predicts BRCA2 inactivation in luminal breast carcinomas.PMID 23754601Read ↗

Deletion of chromosomes 13q and 14q is a common feature of tumors with BRCA2 mutations.Semantic proximity Read ↗

Patterns of loss of heterozygosity at loci from chromosome arm 13q suggests a possible involvement of BRCA2 in sporadic breast tumors.Semantic proximity Read ↗

Loss of heterozygosity in sporadic breast tumours at the BRCA2 locus on chromosome 13q12-q13.Semantic proximity Read ↗

Integrated analysis of copy number and loss of heterozygosity in primary breast carcinomas using high-density SNP array.Semantic proximity Read ↗

Differential patterns of allelic loss in estrogen receptor-positive infiltrating lobular and ductal breast cancer.Semantic proximity Read ↗

Consistent loss of the wild type allele in breast cancers from a family linked to the BRCA2 gene on chromosome 13q12-13.Semantic proximity Read ↗

High-density SNP arrays improve detection of HER2 amplification and polyploidy in breast tumors.Semantic proximity Read ↗

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Frequent occurrence of BRCA2 linkage in Icelandic breast cancer families and segregation of a common BRCA2 haplotype.Semantic proximity Read ↗

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