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Article

Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13.

Science (New York, N.Y.) - 30 Sept 1994

Wooster R, Neuhausen S L, Mangion J, Quirk Y, Ford D, Collins N, Nguyen K, Seal S, Tran T, Averill D

Abstract excerpt

A small proportion of breast cancer, in particular those cases arising at a young age, is due to the inheritance of dominant susceptibility genes conferring a high risk of the disease. A genomic linkage search was performed with 15 high-risk breast cancer families that were unlinked to the BRCA1 locus on chromosome 17q21. This analysis localized a second breast cancer susceptibility locus, BRCA2, to a...

Topics

Breast Neoplasms
Chromosome Mapping
Chromosomes, Human, Pair 13
Female
Genes, Retinoblastoma
Genetic Markers
Genetic Predisposition to Disease
Humans
Lod Score
Male
Ovarian Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pedigree

Phenotype

Source

Identifiers

PMID: 8091231
DOI: 10.1126/science.8091231

Genes

BRCA2
BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8091231-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Related research

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Click a neighbor to travelStep 1 · 12 closest

Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13.PMID 8091231Read ↗

Identification of the breast cancer susceptibility gene BRCA2.Semantic proximity Read ↗

The complete BRCA2 gene and mutations in chromosome 13q-linked kindreds.Semantic proximity Read ↗

Inherited breast cancer.Semantic proximity Read ↗

Confirmation of susceptibility locus on chromosome 13 in Australian breast cancer families.Semantic proximity Read ↗

Somatic deletions in hereditary breast cancers implicate 13q21 as a putative novel breast cancer susceptibility locus.Semantic proximity Read ↗

Genome-wide linkage scan for breast cancer susceptibility loci in Swedish hereditary non-BRCA1/2 families: suggestive linkage to 10q23.32-q25.3.Semantic proximity Read ↗

Mutations of the BRCA1 and BRCA2 genes and the possibilities for predictive testing.Semantic proximity Read ↗

Hereditary premenopausal breast cancer.Semantic proximity Read ↗

Consistent loss of the wild type allele in breast cancers from a family linked to the BRCA2 gene on chromosome 13q12-13.Semantic proximity Read ↗

More breast cancer genes?Semantic proximity Read ↗

A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1.Semantic proximity Read ↗

Frequent occurrence of BRCA2 linkage in Icelandic breast cancer families and segregation of a common BRCA2 haplotype.Semantic proximity Read ↗

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