Article
Peptides control the gain and loss of allele specificity by mutated MHC class I molecules.
Journal of immunology (Baltimore, Md. : 1950) - 1 May 1995
Hengel H, Burke K, Kyburz D, Zinkernagel R M, Koszinowski U H
Abstract excerpt
To analyze the molecular basis of MHC class I allele-restricted peptide recognition, a set of eight Ld/Lq mutants was constructed and tested for peptide recognition by allele-restricted and peptide-specific CTL. The MHC molecules H-2Ld and H-2Lq differ at six amino acid positions (95, 97, 107, 11...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Antigen Presentation
- Antigens, Viral
- Cytotoxicity Tests, Immunologic
- H-2 Antigens
- Lymphocytic choriomeningitis virus
- Mice
- Mice, Inbred BALB C
- Mice, Inbred Strains
- Molecular Sequence Data
- Muromegalovirus
- Mutagenesis, Site-Directed
- Peptides
- T-Lymphocytes, Cytotoxic