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Article

Peptides control the gain and loss of allele specificity by mutated MHC class I molecules.

Journal of immunology (Baltimore, Md. : 1950) - 1 May 1995

Hengel H, Burke K, Kyburz D, Zinkernagel R M, Koszinowski U H

Abstract excerpt

To analyze the molecular basis of MHC class I allele-restricted peptide recognition, a set of eight Ld/Lq mutants was constructed and tested for peptide recognition by allele-restricted and peptide-specific CTL. The MHC molecules H-2Ld and H-2Lq differ at six amino acid positions (95, 97, 107, 116, 155, 157) located within the alpha 2 domain of the molecule. Both molecules present the lymphocytic choriomeningitis...

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PMID: 7722309

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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