Article
Identification of a Tap-dependent leader peptide recognized by alloreactive T cells specific for a class Ib antigen.
Cell - 18 Nov 1994
Aldrich C J, DeCloux A, Woods A S, Cotter R J, Soloski M J, Forman J
Abstract excerpt
Recognition of the class Ib antigen Qa-1 by a portion of alloreactive cytotoxic T lymphocyte (CTL) clones requires that the target cell express a second gene, termed Qa-1 determinant modifier (Qdm). We show that Qdm is identical to most D allele genes, excepting Dk, and that a nonamer peptide derived from D alloantigens restores CTL recognition on cells that lack the Qdm-encoded determinant. The equivalent Dk...
Topics
- Amino Acid Sequence
- Animals
- Clone Cells
- Cytotoxicity, Immunologic
- Endopeptidases
- Epitopes
- Gene Expression
- Genetic Variation
- Histocompatibility Antigens Class I
- Mass Spectrometry
- Mice