Article
Relative implication of peptide residues in binding to major histocompatibility complex class I H-2Db: application to the design of high-affinity, allele-specific peptides.
Molecular immunology - 1 Aug 1995
Hudrisier D, Mazarguil H, Oldstone M B, Gairin J E
Abstract excerpt
The H-2Db peptide sequence SMIENLEYM was manipulated (N- and C-terminus truncation and alanine substitution) to determine the role of structural elements (peptide ends and residue side chains) in binding to H-2Db. We found that good binding affinity could be obtained by compensating the minimal b...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Binding Sites
- CD8-Positive T-Lymphocytes
- Cell Line
- Drug Design
- H-2 Antigens
- Histocompatibility Antigen H-2D
- Mice
- Molecular Sequence Data
- Oligopeptides
- Protein Binding
- Protein Engineering