Article
Binding of peptides lacking consensus anchor residue alters H-2Ld serologic recognition.
Journal of immunology (Baltimore, Md. : 1950) - 15 Nov 1993
Solheim J C, Carreno B M, Smith J D, Gorka J, Myers N B, Wen Z, Martinko J M, Lee D R, Hansen T H
Abstract excerpt
CTL recognize class I MHC/peptide complexes on the surface of target cells. Crystallographic and serologic data have indicated that peptide ligands can influence the conformation of class I molecules and hence T cell recognition. How the binding of peptides with disparate sequence motifs affects the conformation of distinct regions within a class I molecule remains unknown. A series of site-directed mutants of...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Epitopes
- H-2 Antigens
- Histocompatibility Antigen H-2D
- Mice
- Mice, Inbred BALB C
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Mutation