Article
Discriminated selection among viral peptides with the appropriate anchor residues: implications for the size of the cytotoxic T-lymphocyte repertoire and control of viral infection.
Journal of virology - 1 Dec 1995
Oldstone M B, Lewicki H, Borrow P, Hudrisier D, Gairin J E
Abstract excerpt
Structural characterization of peptides restricted by major histocompatibility complex (MHC) class I molecules has identified residues critical for MHC class I binding and for T-cell receptor recognition. For example, optimal peptides fitting into the murine MHC class I Db groove are 9 to 11 amino acids long and require as MHC anchor residues an Asn (N) at position 5 and also either a hydrophobic residue, a Met...
Topics
- Amino Acid Sequence
- Animals
- Binding Sites
- Cell Line
- Cricetinae
- Genetic Variation
- Histocompatibility Antigens Class I
- Kidney
- Lymphocytic choriomeningitis virus
- Mice