Article
CTL escape viral variants. I. Generation and molecular characterization.
Virology - 20 Jun 1995
Lewicki H, Tishon A, Borrow P, Evans C F, Gairin J E, Hahn K M, Jewell D A, Wilson I A, Oldstone M B
Abstract excerpt
Cytotoxic T lymphocytes (CTL) play a pivotal role in preventing persistent viral infections and aborting acute infections. H-2Db-restricted CTL optimally recognize a specific peptide of 9 to 11 amino acids (aa) derived from a viral protein and held in place (restricted) by a MHC class I glycoprotein on the surfaces of infected cells. Only three peptide sequences with the appropriate Db motif from lymphocytic...
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