Article
CTL escape viral variants. I. Generation and molecular characterization.
Virology - 20 Jun 1995
Lewicki H, Tishon A, Borrow P, Evans C F, Gairin J E, Hahn K M, Jewell D A, Wilson I A, Oldstone M B
Abstract excerpt
Cytotoxic T lymphocytes (CTL) play a pivotal role in preventing persistent viral infections and aborting acute infections. H-2Db-restricted CTL optimally recognize a specific peptide of 9 to 11 amino acids (aa) derived from a viral protein and held in place (restricted) by a MHC class I glycoprot...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Cell Line
- Clone Cells
- Computer Simulation
- DNA Primers
- Genetic Variation
- H-2 Antigens
- Lymphocytic choriomeningitis virus
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Models, Molecular
- Molecular Sequence Data
- Peptides
- Phenotype
- Point Mutation