Article
Peptide-induced rescue of serologic epitopes on class I MHC molecules.
Journal of immunology (Baltimore, Md. : 1950) - 1 Feb 1995
Solheim J C, Carreno B M, Myers N B, Lee D R, Hansen T H
Abstract excerpt
To monitor conformational changes in MHC class I structure induced by interaction with peptide or beta 2-microglobulin (beta 2-m), we have taken a serologic approach. Previous studies by us and others have defined circumstances wherein specific peptides can decrease serologic recognition of class I molecules. However, such blocking of serologic epitopes has often been interpreted as steric hindrance by peptide...
Topics
- Amino Acid Sequence
- Animals
- Antibodies, Monoclonal
- Base Sequence
- Epitopes
- Flow Cytometry
- Histocompatibility Antigens Class I
- Mice
- Molecular Sequence Data
- Mutation
- Peptides