Article
A single amino acid substitution in an MHC class I molecule allows heteroclitic recognition by lymphocytic choriomeningitis virus-specific cytotoxic T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) - 15 Aug 1991
Muller D, Pederson K, Murray R, Frelinger J A
Abstract excerpt
Class I molecules of the MHC bind foreign and endogenous peptides allowing recognition by the TCR on CTL. The recognition and killing of cells infected with lymphocytic choriomeningitis virus (LCMV) depends on the recognition of LCMV peptides bound to class I MHC. Mutations in class I MHC molecul...
Topics
- Animals
- Antigens, Differentiation, T-Lymphocyte
- CD8 Antigens
- Cell Line
- Cytotoxicity, Immunologic
- Histocompatibility Antigens Class I
- Lymphocytic choriomeningitis virus
- Mice
- Mice, Inbred C3H
- Mutation
- Protein Conformation
- T-Lymphocytes, Cytotoxic
- Transfection