Article
High peptide affinity for MHC class I does not correlate with immunodominance.
Scandinavian journal of immunology - 1 Oct 1999
Müllbacher A, Lobigs M, Yewdell J W, Bennink J R, Tha Hla R, Blanden R V
Abstract excerpt
Cytotoxic T (Tc)-cell responses against influenza virus infection in BALB/c (H-2d) mice are dominated by Tc clones reactive to the viral nucleoprotein (NP). Here, we report investigations using recombinant vaccinia viruses (VV) encoding major histocompatibility complex (MHC) class I H-2Kd molecules differing by a single amino acid from glutamine (wild-type, Kdw) to histidine (mutant, Kdm) at position 114 located...
Topics
- Animals
- Antigen Presentation
- H-2 Antigens
- Immunodominant Epitopes
- Influenza A virus
- Isoantigens
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C3H
- Mice, Inbred C57BL
- Mutation
- Nucleoproteins
- Orthomyxoviridae Infections
- Peptide Fragments
- Protein Binding
- Recombinant Proteins
- T-Lymphocytes, Cytotoxic
- Vaccinia virus