Article
Infrequent mutation of the p53 gene in fibrous tumors of infancy and childhood.
Diagnostic molecular pathology : the American journal of surgical pathology, part B - 1 Mar 1993
Boman F, Peters J, Ragge N, Triche T
Abstract excerpt
Mutations in the p53 tumor suppressor gene occur in > 50% of human malignancies, but are exceedingly rare in benign tumors. The malignant potential of fibrous tumors of children may be unpredictable at microscopic examination. We therefore sought to determine whether malignant fibrous tumors coul...
Topics
- Adolescent
- Adult
- Child
- Child, Preschool
- DNA Mutational Analysis
- DNA, Neoplasm
- DNA, Single-Stranded
- Female
- Genes, p53
- Humans
- Infant
- Male
- Mutation
- Neoplasms, Fibrous Tissue
- Polymerase Chain Reaction
- Polymorphism, Genetic
- RNA, Neoplasm