Article
Germline Cancer Predisposition Variants in Pediatric Rhabdomyosarcoma: A Report From the Children's Oncology Group.
Journal of the National Cancer Institute - 1 Jul 2021
Li He, Sisoudiya Saumya D, Martin-Giacalone Bailey A, Khayat Michael M, Dugan-Perez Shannon, Marquez-Do Deborah A, Scheurer Michael E, Muzny Donna, Boerwinkle Eric, Gibbs Richard A, Chi Yueh-Yun, Barkauskas Donald A, Lo Tammy, Hall David, Stewart Douglas R, Schiffman Joshua D, Skapek Stephen X, Hawkins Douglas S, Plon Sharon E, Sabo Aniko, Lupo Philip J
Abstract excerpt
BACKGROUND: Several cancer-susceptibility syndromes are reported to underlie pediatric rhabdomyosarcoma (RMS); however, to our knowledge there have been no systematic efforts to characterize the heterogeneous genetic etiologies of this often-fatal malignancy. METHODS: We performed exome-sequencing on germline DNA from 615 patients with newly diagnosed RMS consented through the Children's Oncology Group. We...
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