Article
Constitutional p53 mutations associated with brain tumors in young adults.
Cancer genetics and cytogenetics - 15 Jul 1995
Chen P, Iavarone A, Fick J, Edwards M, Prados M, Israel M A
Abstract excerpt
Identification of patients at risk for developing brain tumors is important for the development of preventative strategies. Because individuals with germline p53 mutations may be at increased risk, we examined DNA from brain tumor-derived cell lines and malignant and normal nervous system tissue for p53 gene mutations using the single strand conformation polymorphism assay and direct sequencing of polymerase...
Topics
- Adult
- Base Sequence
- Brain Neoplasms
- Genes, p53
- Glioma
- Humans
- Meningeal Neoplasms
- Meningioma
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational