Article
Germline mutations of the p53 tumor suppressor gene in children with osteosarcoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 May 1994
McIntyre J F, Smith-Sorensen B, Friend S H, Kassell J, Borresen A L, Yan Y X, Russo C, Sato J, Barbier N, Miser J
Abstract excerpt
PURPOSE: We investigated the possibility that a significant proportion of children with osteosarcoma harbor germline mutations of the p53 tumor suppressor gene and, therefore, this subgroup of pediatric cancer patients should be considered for large-scale predictive testing. PATIENTS AND METHODS:...
Topics
- Base Sequence
- Child
- Codon
- DNA Mutational Analysis
- DNA, Neoplasm
- Electrophoresis, Polyacrylamide Gel
- Exons
- Genes, p53
- Heterozygote
- Humans
- Molecular Sequence Data