Absence of germline and somatic p53 alterations in children with sporadic brain tumors.

doi:10.1023/a:1010661831335

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Article

Absence of germline and somatic p53 alterations in children with sporadic brain tumors.

Journal of neuro-oncology - 1 May 2001

Portwine C, Chilton-MacNeill S, Brown C, Sexsmith E, McLaughlin J, Malkin D

Abstract excerpt

Cancers of the central nervous system are the most common solid tumors of childhood. Although somatic alterations of the p53 tumor suppressor gene have been implicated in brain tumorigenesis, the role of germline p53 mutations in the development of childhood brain tumors has not been well defined. As a component of an ongoing extensive study of the epidemiology of childhood brain tumors, we prospectively examined...

Topics

Brain Neoplasms
Cerebellar Neoplasms
Child
Child, Preschool
Codon
DNA
DNA Mutational Analysis
DNA, Neoplasm
Ganglioglioma
Genes, p53
Genotype
Germ-Line Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Glioma

Humans

Infant

Loss of Heterozygosity

Medulloblastoma

Neuroectodermal Tumors, Primitive

Source

Open in PubMed

Identifiers

PMID: 11519852
DOI: 10.1023/a:1010661831335

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