Article

TP53 Germline Pathogenic Variant Frequency in Anaplastic Rhabdomyosarcoma: A Children’s Oncology Group Report

2022-04-16

Abstract excerpt

Rhabdomyosarcoma (RMS) is a well-described cancer in Li-Fraumeni Syndrome (LFS), resulting from germline TP53 pathogenic variants (PVs). RMS exhibiting anaplasia (anRMS) have been associated with a high rate of germline TP53 PVs. This study provides an updated estimate of the prevalence of TP53 germline PVs from a large cohort of patients (n=239) enrolled in five Children’s Oncology Group (COG) clinical trials. Al...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: dbf2fa48-b7c8-5301-b601-59f12c1b6123
DOI: 10.22541/au.165009784.45190592/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

TP53 Germline Pathogenic Variant Frequency in Anaplastic Rhabdomyosarcoma: A Children’s Oncology Group ReportDOI 10.22541/au.165009784.45190592/v1Read

Anaplastic rhabdomyosarcoma in TP53 germline mutation carriers.Semantic proximity Read

Germline Cancer Predisposition Variants in Pediatric Rhabdomyosarcoma: A Report From the Children's Oncology Group.Semantic proximity Read

A systematic review of the prevalence of pathogenic or likely pathogenic germline variants in individuals with FOXO1 fusion-positive rhabdomyosarcoma.Semantic proximity Read

Genomic Determinants of Clinical Outcomes in Rhabdomyosarcoma.Semantic proximity Read

Identification of TP53 germline variants in pediatric patients undergoing tumor testing: strategy and prevalence.Semantic proximity Read

Pathogenic Germline Variants in Cancer Susceptibility Genes in Children and Young Adults With Rhabdomyosarcoma.Semantic proximity Read

Next-Generation Sequencing Identifies Potential Actionable Targets In Pediatric SarcomasSemantic proximity Read

Identification of an unusual combination of actionable mutations through genomic profiling in a child with an aggressive sarcoma.Semantic proximity Read

Prevalence and clinical implications of germline pathogenic variants in cancer predisposing genes in young patients across sarcoma subtypes.Semantic proximity Read

Sarcomas in TP53 germline mutation carriersSemantic proximity Read

[Genome research project detected TP53mutation in a girl with rhabdomyosarcoma].Semantic proximity Read

Pathogenic germline TP53 mutations in adult sarcoma patients; implications for treatment and screening – description of an upcoming projectSemantic proximity Read