Article
Transgenic expression of human MGMT protects against azoxymethane-induced aberrant crypt foci and G to A mutations in the K-ras oncogene of mouse colon.
Carcinogenesis - 1 Mar 1995
Zaidi N H, Pretlow T P, O'Riordan M A, Dumenco L L, Allay E, Gerson S L
Abstract excerpt
Transgenic mice over-expressing MGMT, which codes for the human protein O6-alkylguanine-DNA alkyltransferase, are protected from methylating agent-induced thymic lymphomas. In this study we evaluated the ability of transgenic overexpression of MGMT in the colon to protect mice from the development of azoxymethane(AOM)-induced aberrant crypt foci (ACF) and mutations in K-ras. Colonic alkyltransferase in MGMT+...
Topics
- Adenine
- Animals
- Azoxymethane
- Base Sequence
- Codon
- Colon
- DNA Primers
- DNA Repair
- Genes, ras
- Guanine
- Humans
- Intestinal Mucosa