Article
Protection against malignant progression of spontaneously developing liver tumors in transgenic mice expressing O(6)-methylguanine-DNA methyltransferase.
Japanese journal of cancer research : Gann - 1 Nov 2000
Qin X, Zhang S, Matsukuma S, Zarkovic M, Shimizu S, Ishikawa T, Nakatsuru Y
Abstract excerpt
To study the effect of O(6)-methylguanine-DNA methyltransferase (MGMT) on carcinogenesis, we have previously generated MGMT transgenic mice overexpressing the bacterial MGMT gene, ada, and demonstrated that high MGMT levels in the liver suppress induction of liver tumors after treatment with an alkylating hepatocarcinogen. To examine the effects of life-long elevation of MGMT activity on mouse spontaneous liver...
Topics
- Animals
- Cell Transformation, Neoplastic
- Female
- Gene Expression Regulation, Neoplastic
- Genes, ras
- Liver Neoplasms, Experimental
- Male
- Mice
- Mice, Inbred C3H
- Mice, Transgenic
- Mutation
- O(6)-Methylguanine-DNA Methyltransferase
- Polymerase Chain Reaction