Increased colon tumor susceptibility in azoxymethane treated CEABAC transgenic mice.

doi:10.1093/carcin/bgl040

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Article

Increased colon tumor susceptibility in azoxymethane treated CEABAC transgenic mice.

Carcinogenesis - 1 Sept 2006

Chan Carlos H F, Cook Denise, Stanners Clifford P

Abstract excerpt

Human carcinoembryonic antigen (CEA), a widely used clinical tumor marker, and its close relative, CEACAM6, are often overexpressed in many cancers. This correlation suggests a possible instrumental role in tumorigenesis, which is supported by extensive results obtained with several in vitro systems. The implication that these results could also apply in vivo warrants investigation. Since mice do not possess...

Topics

Animals
Antigens, CD
Azoxymethane
Carcinoembryonic Antigen
Carcinogens
Cell Adhesion Molecules
Colonic Neoplasms
GPI-Linked Proteins
Gene Expression Regulation, Neoplastic
Genetic Predisposition to Disease
Glycosylphosphatidylinositols
Humans
Mice
Mice, Transgenic
Mutation
beta Catenin

Source

Open in PubMed

Identifiers

PMID: 16632476
DOI: 10.1093/carcin/bgl040

Genes

CEACAM6
CEACAM7
GPI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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