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Article

Alkylation-induced colon tumorigenesis in mice deficient in the Mgmt and Msh6 proteins.

Oncogene - 5 Feb 2009

Bugni J M, Meira L B, Samson L D

Abstract excerpt

O(6)-methylguanine DNA methyltransferase (MGMT) suppresses mutations and cell death that result from alkylation damage. MGMT expression is lost by epigenetic silencing in a variety of human cancers including nearly half of sporadic colorectal cancers, suggesting that this loss maybe causal. Using mice with a targeted disruption of the Mgmt gene, we tested whether Mgmt protects against azoxymethane (AOM)-induced...

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Share to Alkylating Agents
Share to Alkylation
Share to Azoxymethane

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Dextran Sulfate

Share to DNA Modification Methylases

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Source

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Identifiers

PMID: 19029948
DOI: 10.1038/onc.2008.426
PMCID: PMC3557788

Genes

MGMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Alkylation-induced colon tumorigenesis in mice deficient in the Mgmt and Msh6 proteins.PMID 19029948Read ↗

Impact of Dnmt1 deficiency, with and without low folate diets, on tumor numbers and DNA methylation in Min mice.Semantic proximity Read ↗

The associated contributions of p53 and the DNA mismatch repair protein Msh6 to spontaneous tumorigenesis.Semantic proximity Read ↗

The DNA mismatch repair genes Msh3 and Msh6 cooperate in intestinal tumor suppression.Semantic proximity Read ↗

Aberrant DNA methylation occurs in colon neoplasms arising in the azoxymethane colon cancer modelSemantic proximity Read ↗

Transgenic expression of human MGMT protects against azoxymethane-induced aberrant crypt foci and G to A mutations in the K-ras oncogene of mouse colon.Semantic proximity Read ↗

Mlh1 deficiency enhances several phenotypes of Apc(Min)/+ mice.Semantic proximity Read ↗

Inhibition of O(6)-methylguanine-DNA methyltransferase increases azoxymethane-induced colonic tumors in rats.Semantic proximity Read ↗

HNPCC-like cancer predisposition in mice through simultaneous loss of Msh3 and Msh6 mismatch-repair protein functions.Semantic proximity Read ↗

Dnmt1N/+ reduces the net growth rate and multiplicity of intestinal adenomas in C57BL/6-multiple intestinal neoplasia (Min)/+ mice independently of p53 but demonstrates strong synergy with the modifier of Min 1(AKR) resistance allele.Semantic proximity Read ↗

Msh2 deficiency enhances somatic Apc and p53 mutations in Apc+/-Msh2-/- mice.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase deficiency and low dietary folate reduce tumorigenesis in Apc min/+ mice.Semantic proximity Read ↗

Mutational-reporter transgenes rescued from mice lacking either Mgmt, or both Mgmt and Msh6 suggest that O6-alkylguanine-induced miscoding does not contribute to the spontaneous mutational spectrum.Semantic proximity Read ↗

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