Clonal overexpression of metallothionein is induced by somatic mutation in morphologically normal colonic mucosa.

doi:10.1002/(SICI)1096-9896(199802)184:2<144::AID-PATH998>3.0.CO;2-J

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Article

Clonal overexpression of metallothionein is induced by somatic mutation in morphologically normal colonic mucosa.

The Journal of pathology - 1 Feb 1998

Jasani B, Campbell F, Navabi H, Schmid K W, Williams G T

Abstract excerpt

Metallothionein (MT) overexpression occurs frequently in human tumours but the underlying mechanism is unknown. Morphologically normal-appearing mucosa from human colorectal carcinoma resection specimens and of the colons of ageing laboratory mice contains scattered single crypts whose cells show...

Topics

1,2-Dimethylhydrazine
Animals
Clone Cells
Colon
Colorectal Neoplasms
Female
Gene Expression
Intestinal Mucosa
Male
Metallothionein
Mice
Mice, Inbred BALB C
Mutagens
Mutation
Neoplasm Proteins

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