Article
Characterization of c-myc-transformed rat fibroblasts resistant to apoptosis induced ny growth factor deprivation.
Experimental cell research - 10 Apr 1996
Dhanaraj S N, Marcus A M, Korah R M, Iwata K, Small M B
Abstract excerpt
Under appropriate conditions (e.g., growth factor withdrawal), the deregulated expression of c-myc in rodent fibroblasts leads to substantial cell death due to apoptosis. To better understand this process, we selected for c-myc-transformed Rat1A fibroblasts that were resistant to growth factor de...
Topics
- Alkaloids
- Animals
- Apoptosis
- Cell Division
- Cell Transformation, Neoplastic
- Cells, Cultured
- Culture Media, Serum-Free
- Enzyme Inhibitors
- Fibroblasts
- Genes, myc
- Growth Substances
- Humans
- Phenotype
- Protein Kinase Inhibitors
- Proto-Oncogene Proteins c-myc
- Rats
- Staurosporine
- Tumor Suppressor Protein p53