Article
Decreased DNA topoisomerase II alpha expression and cold-sensitive growth in a mouse mammary cancer cell line resistant to etoposide and doxorubicin.
Oncology research - 1 Jan 1996
Kawanami K, Nakamura T, Ono M, Kusano T, Okada K, Kikuchi A, Adachi N, Kohno K, Higashi K, Kuwano M
Abstract excerpt
A mouse mammary carcinoma FM3A cell line resistant to the DNA topoisomerase (topo) II-targeting agent, etoposide (VP-16), FM3A/VP-2B, had a markedly reduced growth rate at a low temperature (33 degrees C). The cells had the following properties: (a) FM3A/VP-2B, which had 24-fold higher resistance...
Topics
- Amino Acid Sequence
- Animals
- Antibiotics, Antineoplastic
- Antigens, Neoplasm
- Antineoplastic Agents, Phytogenic
- Blotting, Northern
- Cell Division
- Cold Temperature
- DNA Topoisomerases, Type I
- DNA Topoisomerases, Type II
- DNA-Binding Proteins
- Doxorubicin
- Drug Resistance
- Etoposide