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Decreased DNA topoisomerase II alpha expression and cold-sensitive growth in a mouse mammary cancer cell line resistant to etoposide and doxorubicin.

Oncology research - 1 Jan 1996

Kawanami K, Nakamura T, Ono M, Kusano T, Okada K, Kikuchi A, Adachi N, Kohno K, Higashi K, Kuwano M

Abstract excerpt

A mouse mammary carcinoma FM3A cell line resistant to the DNA topoisomerase (topo) II-targeting agent, etoposide (VP-16), FM3A/VP-2B, had a markedly reduced growth rate at a low temperature (33 degrees C). The cells had the following properties: (a) FM3A/VP-2B, which had 24-fold higher resistance to VP-16 than its parental line, FM3A, was cross-resistant to doxorubicin, but not to a camptothecin derivative,...

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PMID: 8884812

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