Article
Chronic exposure of cultured transformed mouse epidermal cells to transforming growth factor-beta 1 induces an epithelial-mesenchymal transdifferentiation and a spindle tumoral phenotype.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Aug 1995
Caulín C, Scholl F G, Frontelo P, Gamallo C, Quintanilla M
Abstract excerpt
Transformed mouse epidermal keratinocytes of the cell line PDV, when cultured under the presence of transforming growth factor-beta 1 (TGF-beta 1), escaped the block of growth exerted by this factor in normal keratinocytes and underwent marked changes in cell differentiation. TGF-beta 1 induced d...
Topics
- Animals
- Biomarkers
- Carcinoma, Squamous Cell
- Cell Differentiation
- Cell Line, Transformed
- Chronic Disease
- Epithelial Cells
- Epithelium
- Injections
- Keratinocytes
- Mesoderm
- Mice
- Mice, Nude
- Phenotype
- Transforming Growth Factor beta