Article
Chronic exposure of cultured transformed mouse epidermal cells to transforming growth factor-beta 1 induces an epithelial-mesenchymal transdifferentiation and a spindle tumoral phenotype.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Aug 1995
Caulín C, Scholl F G, Frontelo P, Gamallo C, Quintanilla M
Abstract excerpt
Transformed mouse epidermal keratinocytes of the cell line PDV, when cultured under the presence of transforming growth factor-beta 1 (TGF-beta 1), escaped the block of growth exerted by this factor in normal keratinocytes and underwent marked changes in cell differentiation. TGF-beta 1 induced disruption of epithelial interactions, dispersion of cells, increased local movement, and conversion to a...
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