Loss of Desmocollin 3 in skin tumor development and progression.

doi:10.1002/mc.20818

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Article

Loss of Desmocollin 3 in skin tumor development and progression.

Molecular carcinogenesis - 1 Jul 2012

Chen Jiangli, O'Shea Charlene, Fitzpatrick James E, Koster Maranke I, Koch Peter J

Abstract excerpt

Desmocollin 3 (DSC3) is a desmosomal cadherin that is required for maintaining cell adhesion in the epidermis as demonstrated by the intra-epidermal blistering observed in Dsc3 null skin. Recently, it has been suggested that deregulated expression of DSC3 occurs in certain human tumor types. It is not clear whether DSC3 plays a role in the development or progression of cancers arising in stratified epithelia such...

Topics

Alleles
Animals
Biomarkers, Tumor
Carcinoma, Squamous Cell
Desmocollins
Disease Progression
Genes, ras
Humans
Membrane Glycoproteins
Mice
Skin Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 21681825
DOI: 10.1002/mc.20818
PMCID: PMC3178010

Genes

DSC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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