Article
Transforming growth factor beta 1 induces squamous carcinoma cell variants with increased metastatic abilities and a disorganized cytoskeleton.
Experimental cell research - 1 Nov 1998
Frontelo P, González-Garrigues M, Vilaró S, Gamallo C, Fabra A, Quintanilla M
Abstract excerpt
Previous studies indicated that mouse transformed keratinocytes undergo an epithelial-fibroblastic conversion when cultured in the presence of TGF-beta1. This conversion is associated in vivo with a squamous-spindle carcinoma transition. We derived epithelioid (A6, FPA6) and spindle (B5) clonal c...
Topics
- Animals
- Carcinoma, Squamous Cell
- Cell Differentiation
- Cell Division
- Cell Transformation, Neoplastic
- Cytoskeleton
- Epithelial Cells
- Fibroblasts
- Male
- Mice
- Mice, Inbred BALB C
- Mice, Nude
- Neoplasm Proteins
- Phenotype
- Transforming Growth Factor beta
- Tumor Cells, Cultured