Article
Cell adhesion and tumor progression in mouse skin carcinogenesis: increased synthesis and organization of fibronectin is associated with the undifferentiated spindle phenotype.
Invasion & metastasis - 1 Jan 2000
Gómez M, Navarro P, Cano A
Abstract excerpt
The expression and organization of the extracellular matrix component fibronectin has been analyzed in a collection of murine epidermal keratinocyte cell lines representative of different stages of mouse skin carcinogenesis. The fibroblastoid phenotype of spindle cells has been found to be associated with high levels of fibronectin expression and the ability to organize this molecule in an extracellular matrix....
Topics
- Animals
- Carcinoma
- Carcinoma, Squamous Cell
- Cell Adhesion
- Cell Adhesion Molecules
- Cell Movement
- Cell Transformation, Neoplastic
- Disease Progression
- Extracellular Matrix
- Fibronectins