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Article

A Role for Endoglin as a Suppressor of Malignancy during Mouse Skin Carcinogenesis

1 Nov 2007

Abstract excerpt

Endoglin is a membrane glycoprotein that acts as a coreceptor for transforming growth factor-beta. We and others have previously suggested a function of endoglin as a tumor suppressor in epithelial cancer. Here, we study the expression of endoglin during chemical mouse skin carcinogenesis. We find that shedding of membrane endoglin, allowing the secretion of a soluble endoglin form, is a late event associated...

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PMID: 17974968
DOI: 10.1158/0008-5472.can-07-1348

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