Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular analysis of mutations in the hprt gene in circulating lymphocytes from normal and DNA-repair-deficient donors.

Mutation research - 1 Jun 1993

Steingrimsdottir H, Rowley G, Waugh A, Beare D, Ceccherini I, Cole J, Lehmann A R

Abstract excerpt

Circulating lymphocytes from patients with the DNA-repair-deficient disorders, xeroderma pigmentosum (XP) and ataxia telangiectasia (A-T) have elevated frequencies of mutants at the hypoxanthine-guanine phosphoribosyltransferase (hprt) locus. We have analysed the DNA sequence of the hprt gene in mutants from normal donors, and compared them with mutants from XP and A-T individuals. In normal donors we found a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Child
Share to DNA Mutational Analysis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Repair

Share to Genetic Complementation Test

Share to Mutation

Share to Point Mutation

Share to Polymerase Chain Reaction

Source

Identifiers

PMID: 7683756
DOI: 10.1016/0921-8777(93)90055-l

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular analysis of mutations in the hprt gene in circulating lymphocytes from normal and DNA-repair-deficient donors.PMID 7683756Read ↗

Elevated hprt mutant frequency in circulating T-lymphocytes of xeroderma pigmentosum patients.Semantic proximity Read ↗

Molecular analysis of ultraviolet-induced mutations in a xeroderma pigmentosum cell line.Semantic proximity Read ↗

Quantification and molecular characterization of hprt mutants of human T-lymphocytes.Semantic proximity Read ↗

Characterization of in vivo somatic mutations at the hypoxanthine phosphoribosyltransferase gene of a human control population.Semantic proximity Read ↗

Splicing mutations at the HPRT locus in human T-lymphocytes in vivo.Semantic proximity Read ↗

DNA sequence analysis of in vivo hprt mutation in human T lymphocytes.Semantic proximity Read ↗

V(D)J recombinase-like activity mediates hprt gene deletion in human fetal T-lymphocytes.Semantic proximity Read ↗

In vivo somatic mutations in human lymphocytes frequently result from major gene alterations.Semantic proximity Read ↗

Molecular analysis of mutations affecting hprt mRNA splicing in human T-lymphocytes in vivo.Semantic proximity Read ↗

Novel types of mutation identified at the hprt locus of human T-lymphocytes.Semantic proximity Read ↗

Molecular analysis of mutations in the human HPRT gene.Semantic proximity Read ↗

Molecular analysis of mutations in the human HPRT gene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.