Article
Molecular analysis of mutations in the hprt gene in circulating lymphocytes from normal and DNA-repair-deficient donors.
Mutation research - 1 Jun 1993
Steingrimsdottir H, Rowley G, Waugh A, Beare D, Ceccherini I, Cole J, Lehmann A R
Abstract excerpt
Circulating lymphocytes from patients with the DNA-repair-deficient disorders, xeroderma pigmentosum (XP) and ataxia telangiectasia (A-T) have elevated frequencies of mutants at the hypoxanthine-guanine phosphoribosyltransferase (hprt) locus. We have analysed the DNA sequence of the hprt gene in...
Topics
- Adult
- Age Factors
- Aged
- Ataxia Telangiectasia
- Child
- DNA Mutational Analysis
- DNA Repair
- Gene Rearrangement, T-Lymphocyte
- Genetic Complementation Test
- Humans
- Hypoxanthine Phosphoribosyltransferase
- Lymphocytes
- Male
- Middle Aged
- Mutation
- Point Mutation
- Polymerase Chain Reaction
- Receptors, Antigen, T-Cell