In vivo somatic mutations in human lymphocytes frequently result from major gene alterations.

doi:10.1038/315343a0

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Article

In vivo somatic mutations in human lymphocytes frequently result from major gene alterations.

Nature - 1 Jan 2000

Turner D R, Morley A A, Haliandros M, Kutlaca R, Sanderson B J

Abstract excerpt

Somatic mutations, either spontaneous or produced by identifiable mutagens, are thought to be important in the aetiology of cancer and in the ageing process. The study of somatic mutations in human cells in vivo has recently been made possible by the development of techniques for enumeration and...

Topics

Aging
Base Sequence
Cells, Cultured
Genes
Humans
Hypoxanthine Phosphoribosyltransferase
Lymphocytes
Male
Mutation
Neoplasms
Polymorphism, Genetic

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