Article
V(D)J recombinase-like activity mediates hprt gene deletion in human fetal T-lymphocytes.
Cancer research - 1 Nov 1991
Fuscoe J C, Zimmerman L J, Lippert M J, Nicklas J A, O'Neill J P, Albertini R J
Abstract excerpt
Studies from several laboratories worldwide have developed a large database for in vivo hypoxanthine-guanine phosphoribosyltransferase gene mutations in human T-lymphocytes. Sufficient differences have been found thus far between the spectrum for spontaneous mutations in adults and that observed in the fetus to suggest fundamental differences in in vivo mutagenic mechanisms at these two life stages. In adults,...
Topics
- Base Sequence
- Cells, Cultured
- Chromosome Deletion
- Clone Cells
- DNA Nucleotidyltransferases
- Exons
- Gene Expression Regulation, Enzymologic
- Humans
- Hypoxanthine Phosphoribosyltransferase
- Infant, Newborn
- Introns