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Article

DNA sequence analysis of in vivo hprt mutation in human T lymphocytes.

Mutagenesis - 1 Sept 1990

Recio L, Cochrane J, Simpson D, Skopek T R, O'Neill J P, Nicklas J A, Albertini R J

Abstract excerpt

We have determined the molecular basis of hypoxanthine-guanine phosphoribosyltransferase (hprt) mutations that arose in vivo in the T lymphocytes of a normal male subject. In previous studies approximately 16% (23/141) of the mutants from this individual analyzed by Southern blot displayed large structural alterations in hprt. Thirty-two mutants without these large hprt structural alterations produced sufficient...

Topics

Base Sequence
Cells, Cultured
DNA
Exons
Gene Rearrangement, T-Lymphocyte
Humans
Hypoxanthine Phosphoribosyltransferase
Introns
Male
Molecular Sequence Data
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymerase Chain Reaction

T-Lymphocytes

Source

Identifiers

PMID: 2263208
DOI: 10.1093/mutage/5.5.505

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2263208-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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