Splicing mutations at the HPRT locus in human T-lymphocytes in vivo.

Article

Splicing mutations at the HPRT locus in human T-lymphocytes in vivo.

Environmental and molecular mutagenesis - 1 Jan 1998

Osterholm A M, Hou S M

Abstract excerpt

We studied 58 splicing mutations originating in vivo at the hypoxanthine guanine phosphoribosyltransferase (HPRT) locus in T-cells of 30 nonsmoking males. A nonrandom distribution of skipped exons was seen after cDNA sequence analysis, with 71% involving exons 2-3 (15), 4 (11), and 8 (15). The mu...

Topics

Base Sequence
DNA Primers
Humans
Hypoxanthine Phosphoribosyltransferase
Mutation
RNA Splicing
T-Lymphocytes

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