Elevated hprt mutant frequency in circulating T-lymphocytes of xeroderma pigmentosum patients.

doi:10.1016/0921-8777(92)90078-h

Back to search

Article

Elevated hprt mutant frequency in circulating T-lymphocytes of xeroderma pigmentosum patients.

Mutation research - 1 Mar 1992

Cole J, Arlett C F, Norris P G, Stephens G, Waugh A P, Beare D M, Green M H

Abstract excerpt

The mutant frequency to 6-thioguanine resistance in circulating T-lymphocytes from 10 xeroderma pigmentosum patients (including complementation groups D and G and XP variants) has been determined. A highly significantly elevated frequency was observed, compared to age-matched, non-smoking control...

Topics

Adult
Aged
Child
Drug Resistance
Female
Humans
Hypoxanthine Phosphoribosyltransferase
Male
Middle Aged
Mutation
Smoking
T-Lymphocytes
Thioguanine
Xeroderma Pigmentosum

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.