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Article

Molecular analysis of mutations affecting hprt mRNA splicing in human T-lymphocytes in vivo.

Environmental and molecular mutagenesis - 1 Jan 1992

Rossi A M, Tates A D, van Zeeland A A, Vrieling H

Abstract excerpt

Molecular analysis of hypoxanthine-guanine phosphoribosyltransferase (hprt) cDNA from 6-thioguanine-resistant T-lymphocytes cloned from smoking and non-smoking adult donors showed that 35% of these mutants were defective in splicing of hprt mRNA. Among a set of 42 hprt splice mutants, we observed...

Topics

Adult
Base Sequence
Cells, Cultured
Exons
Humans
Hypoxanthine Phosphoribosyltransferase
Introns
Molecular Sequence Data
Mutation
Polymerase Chain Reaction
RNA Splicing
RNA, Messenger

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Smoking

T-Lymphocytes

Source

Identifiers

PMID: 1732105
DOI: 10.1002/em.2850190103

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1732105-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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