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Article

Molecular analysis of mutations affecting hprt mRNA splicing in human T-lymphocytes in vivo.

Environmental and molecular mutagenesis - 1 Jan 1992

Rossi A M, Tates A D, van Zeeland A A, Vrieling H

Abstract excerpt

Molecular analysis of hypoxanthine-guanine phosphoribosyltransferase (hprt) cDNA from 6-thioguanine-resistant T-lymphocytes cloned from smoking and non-smoking adult donors showed that 35% of these mutants were defective in splicing of hprt mRNA. Among a set of 42 hprt splice mutants, we observed i) complete loss of one or more exons, ii) partial loss of one exon, or iii) inclusion of part of an intron sequence...

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Identifiers

PMID: 1732105
DOI: 10.1002/em.2850190103

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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