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Article

Functional characterization in vivo of mutant p53 molecules derived from squamous cell carcinomas of the head and neck.

Molecular carcinogenesis - 1 Feb 1997

Cardinali M, Kratochvil F J, Ensley J F, Robbins K C, Yeudall W A

Abstract excerpt

Loss of wild-type p53, either through deletion or mutation, has been demonstrated in most squamous cell carcinomas of the head and neck (HNSCC). Whether these mutant molecules contribute to tumor progression purely through loss of wild-type functions or by growth-promoting mechanisms, however, remains unclear. To begin to address these issues, we isolated a series of p53 cDNAs from HNSCC cell lines that contain...

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Identifiers

PMID: 9049183
DOI: 10.1002/(sici)1098-2744(199702)18:2<78::aid-mc3>3.0.co;2-m

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