Article
Functional characterization in vivo of mutant p53 molecules derived from squamous cell carcinomas of the head and neck.
Molecular carcinogenesis - 1 Feb 1997
Cardinali M, Kratochvil F J, Ensley J F, Robbins K C, Yeudall W A
Abstract excerpt
Loss of wild-type p53, either through deletion or mutation, has been demonstrated in most squamous cell carcinomas of the head and neck (HNSCC). Whether these mutant molecules contribute to tumor progression purely through loss of wild-type functions or by growth-promoting mechanisms, however, re...
Topics
- 3T3 Cells
- Animals
- Carcinoma, Squamous Cell
- Female
- Gene Expression Regulation, Neoplastic
- Genes, p53
- Head and Neck Neoplasms
- Humans
- Immunohistochemistry
- Mice
- Mice, Nude
- Mutation
- Neoplasm Transplantation
- Neoplasms, Experimental
- Plasmids
- Transfection
- Tumor Cells, Cultured