Article
Presentation of endogenous peptides to MHC class I-restricted cytotoxic T lymphocytes in transport deletion mutant T2 cells.
Journal of immunology (Baltimore, Md. : 1950) - 1 Mar 1993
Zweerink H J, Gammon M C, Utz U, Sauma S Y, Harrer T, Hawkins J C, Johnson R P, Sirotina A, Hermes J D, Walker B D
Abstract excerpt
The ability of minigene-encoded viral peptide epitopes to be presented by class I molecules in the absence of MHC-encoded transporters has been evaluated in mutant T2 cells. These cells have a large deletion in the class II MHC region that includes the known transporter protein for antigenic peptides and proteasome genes and they are defective in presenting viral epitopes to CTL. T2 cells that express minigenes...
Topics
- Amino Acid Sequence
- Biological Transport
- Gene Deletion
- Gene Expression
- Gene Products, tax
- HLA-A2 Antigen
- HLA-B27 Antigen
- Humans
- Molecular Sequence Data
- Mutation