Article
Peptide transporter-independent, stress protein-mediated endosomal processing of endogenous protein antigens for major histocompatibility complex class I presentation.
European journal of immunology - 1 Jul 1994
Schirmbeck R, Reimann J
Abstract excerpt
The peptide transporter-defective cell line RMA-S expressing the wild-type simian virus 40 large T antigen (wtT-Ag) from a transfected gene did not present two well-defined, H-2 class I (Db)-restricted epitopes of T-Ag to cytotoxic T lymphocytes (CTL). Hence, "endogenous" processing and presentat...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 3
- ATP-Binding Cassette Transporters
- Amino Acid Sequence
- Animals
- Antigen Presentation
- Antigens, Polyomavirus Transforming
- Biological Transport
- Carrier Proteins
- Cell Line
- Cytotoxicity Tests, Immunologic
- H-2 Antigens
- Heat-Shock Proteins
- Mice
- Mice, Inbred C57BL
- Molecular Sequence Data
- Mutation
- Recombinant Proteins
- T-Lymphocytes, Cytotoxic