Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Peptide transporter-independent, stress protein-mediated endosomal processing of endogenous protein antigens for major histocompatibility complex class I presentation.

European journal of immunology - 1 Jul 1994

Schirmbeck R, Reimann J

Abstract excerpt

The peptide transporter-defective cell line RMA-S expressing the wild-type simian virus 40 large T antigen (wtT-Ag) from a transfected gene did not present two well-defined, H-2 class I (Db)-restricted epitopes of T-Ag to cytotoxic T lymphocytes (CTL). Hence, "endogenous" processing and presentation of the wtT-Ag depended on a functional peptide transporter heterodimer. In contrast, both T-Ag epitopes were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Carrier Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cell Line

Share to Mice, Inbred C57BL

Share to Molecular Sequence Data

Share to Mutation

Share to Recombinant Proteins

Source

Identifiers

PMID: 8026512
DOI: 10.1002/eji.1830240704

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Peptide transporter-independent, stress protein-mediated endosomal processing of endogenous protein antigens for major histocompatibility complex class I presentation.PMID 8026512Read ↗

Presentation of endogenous peptides to MHC class I-restricted cytotoxic T lymphocytes in transport deletion mutant T2 cells.Semantic proximity Read ↗

Major histocompatibility complex (MHC)-encoded HAM2 is necessary for antigenic peptide loading onto class I MHC molecules.Semantic proximity Read ↗

Presentation of cytosolic antigen by HLA-DR requires a function encoded in the class II region of the MHC.Semantic proximity Read ↗

Noncovalent association with stress protein facilitates cross-priming of CD8+ T cells to tumor cell antigens by dendritic cells.Semantic proximity Read ↗

Presentation of newly synthesized glycoproteins to CD4+ T lymphocytes. An analysis using influenza hemagglutinin transport mutants.Semantic proximity Read ↗

Mutation of the invariant chain transmembrane region inhibits II degradation, prolongs association with MHC class II, and selectively disrupts antigen presentation.Semantic proximity Read ↗

Physical and functional association of the major histocompatibility complex class I heavy chain alpha3 domain with the transporter associated with antigen processing.Semantic proximity Read ↗

Restoration of antigen presentation to the mutant cell line RMA-S by an MHC-linked transporter.Semantic proximity Read ↗

HLA-A2 molecules in an antigen-processing mutant cell contain signal sequence-derived peptides.Semantic proximity Read ↗

Cytosolic aminopeptidases influence MHC class I-mediated antigen presentation in an allele-dependent manner.Semantic proximity Read ↗

The impact of misfolding versus targeted degradation on the efficiency of the MHC class I-restricted antigen processing.Semantic proximity Read ↗

The RMA-S lymphoma mutant; consequences of a peptide loading defect on immunological recognition and graft rejection.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.