Article
Genetic evidence for difference between intracellular and extracellular peptides in influenza A matrix peptide-specific CTL recognition.
Journal of immunology (Baltimore, Md. : 1950) - 1 Feb 1995
Matsui M, Moots R J, Warburton R J, Peace-Brewer A L, Tussey L G, Quinn D G, McMichael A J, Frelinger J A
Abstract excerpt
During the course of extensive mutagenesis of HLA-A2.1, we examined influenza A matrix peptide (FMP)-specific CTL recognition of HMy2.C1R (C1R) cells expressing mutant HLA-A2.1 molecules, sensitized with synthetic peptide, FMP 58-66, (exogenous peptide), or infected with influenza A virus (endoge...
Topics
- Amino Acid Sequence
- Antigen Presentation
- Blotting, Western
- Cell Line
- Cytotoxicity Tests, Immunologic
- HLA-A2 Antigen
- Humans
- Influenza A virus
- Molecular Sequence Data
- Mutation
- Peptides
- T-Lymphocytes, Cytotoxic
- Transfection
- Viral Matrix Proteins