Article
Analysis of the mutant HLA-A*0201 heavy chain H74L: impaired TAP-dependent peptide loading.
Human immunology - 1 Sept 1999
Caley R R, Peace-Brewer A L, Matsui M, Frelinger J A
Abstract excerpt
A mutation of the HLA-A*0201 heavy chain at position 74 from histidine to leucine (H74L) resulted in a molecule with an interesting phenotype. H74L-expressing targets were recognized by peptide-specific HLA-A*0201-restricted cytotoxic T lymphocytes at lower peptide concentrations than wild type HLA-A*0201. H74L's improved ability to sensitize cells for tysis was due to its enhanced capability to bind exogenous...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 2
- ATP Binding Cassette Transporter, Subfamily B, Member 3
- ATP-Binding Cassette Transporters
- Antigen Presentation
- Biological Transport
- Gene Products, pol
- HIV-1
- HLA-A2 Antigen
- Histocompatibility Antigens Class I
- Humans
- Intracellular Fluid
- Mutation
- Peptides
- Proteins
- Tumor Cells, Cultured
- Viral Matrix Proteins