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Article

Analysis of the mutant HLA-A*0201 heavy chain H74L: impaired TAP-dependent peptide loading.

Human immunology - 1 Sept 1999

Caley R R, Peace-Brewer A L, Matsui M, Frelinger J A

Abstract excerpt

A mutation of the HLA-A*0201 heavy chain at position 74 from histidine to leucine (H74L) resulted in a molecule with an interesting phenotype. H74L-expressing targets were recognized by peptide-specific HLA-A*0201-restricted cytotoxic T lymphocytes at lower peptide concentrations than wild type HLA-A*0201. H74L's improved ability to sensitize cells for tysis was due to its enhanced capability to bind exogenous...

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PMID: 10527381
DOI: 10.1016/s0198-8859(99)00022-1

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