Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Peptide-dependent expression of HLA-B7 on antigen processing-deficient T2 cells.

Journal of immunology (Baltimore, Md. : 1950) - 15 May 1996

Smith K D, Lutz C T

Abstract excerpt

Class I MHC Ag presentation and cell surface expression largely depend on peptide transport into the ER/cis-Golgi by TAP, the transporter associated with Ag processing. Despite this dependency, class I MHC molecules are expressed at low levels on the surface of TAP-deficient T2 cells. We studied the peptide dependency of HLA-B7 expression in transfected T2 cells. HLA-B7 expression was affected by mutations at 19...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigen Presentation
Share to Antigen-Presenting Cells
Share to ATP Binding Cassette Transporter, Subfamily B, Member 3

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to ATP-Binding Cassette Transporters

Share to Cell Line

Share to Histocompatibility Antigens Class I

Share to Mutation

Share to Protein Binding

Source

Identifiers

PMID: 8621911

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Peptide-dependent expression of HLA-B7 on antigen processing-deficient T2 cells.PMID 8621911Read ↗

Allele-specific differences in the interaction of MHC class I molecules with transporters associated with antigen processing.Semantic proximity Read ↗

Expression of HLA class I antigens in transporter associated with antigen processing (TAP)-deficient mutant cell lines.Semantic proximity Read ↗

Dependence of peptide binding by MHC class I molecules on their interaction with TAP.Semantic proximity Read ↗

Recruitment of MHC class I molecules by tapasin into the transporter associated with antigen processing-associated complex is essential for optimal peptide loading.Semantic proximity Read ↗

Analysis of the mutant HLA-A*0201 heavy chain H74L: impaired TAP-dependent peptide loading.Semantic proximity Read ↗

HLA-E surface expression depends on binding of TAP-dependent peptides derived from certain HLA class I signal sequences.Semantic proximity Read ↗

The Transporter Associated With Antigen Processing (TAP): Structural Integrity, Expression, Function, and Its Clinical RelevanceSemantic proximity Read ↗

Multiplexed functional analysis of TAP2 variants in regulating MHC-I cell surface abundance reveals overexpression of PLK1 downregulates antigen presentationSemantic proximity Read ↗

Allele-dependent processing pathways generate the endogenous human leukocyte antigen (HLA) class I peptide repertoire in transporters associated with antigen processing (TAP)-deficient cells.Semantic proximity Read ↗

A point mutation in the human transporter associated with antigen processing (TAP2) alters the peptide transport specificity.Semantic proximity Read ↗

HLA-B27-restricted antigen presentation in the absence of tapasin reveals polymorphism in mechanisms of HLA class I peptide loading.Semantic proximity Read ↗

Quantitative and Qualitative Influences of Tapasin on the Class I Peptide RepertoireSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.