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Article

Presentation of cytosolic antigen by HLA-DR requires a function encoded in the class II region of the MHC.

Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 1993

Malnati M S, Ceman S, Weston M, DeMars R, Long E O

Abstract excerpt

The processing pathway for the MHC class II-restricted presentation of endogenous cytosolic Ag is distinct from the class I pathway since a cytosolic form of the influenza virus A hemagglutinin, expressed by a recombinant vaccinia virus, was presented by HLA-DR in a B cell mutant lacking the TAP1...

Topics

Antigen Presentation
B-Lymphocytes
Cell Line
Cytosol
Cytotoxicity, Immunologic
Genes, MHC Class II
HLA-DR Antigens
Hemagglutinin Glycoproteins, Influenza Virus
Hemagglutinins, Viral
Humans
Mutation
Transfection

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 8258689

Genes

TAP1
TAP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8258689-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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