Article
The sequential accumulation of genetic alterations characteristic of the colorectal adenoma-carcinoma sequence does not occur between gastric adenoma and adenocarcinoma.
The Journal of pathology - 1 Jul 1995
Maesawa C, Tamura G, Suzuki Y, Ogasawara S, Sakata K, Kashiwaba M, Satodate R
Abstract excerpt
We screened 30 gastric adenomas and 72 gastric adenocarcinomas for four genetic alterations (mutations of the K-ras, APC, and p53 genes and loss of heterozygosity at the DCC genetic locus) which are known to occur during colorectal tumourigenesis. We used polymerase chain reaction (PCR) single-st...
Topics
- Adenocarcinoma
- Adenoma
- Base Sequence
- Colorectal Neoplasms
- Disease Progression
- Genes, APC
- Genes, DCC
- Genes, p53
- Genes, ras
- Humans
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational
- Stomach Neoplasms