Article
Mutations in APC, Kirsten-ras, and p53--alternative genetic pathways to colorectal cancer.
Proceedings of the National Academy of Sciences of the United States of America - 9 Jul 2002
Smith Gillian, Carey Francis A, Beattie Julie, Wilkie Murray J V, Lightfoot Tracy J, Coxhead Jonathan, Garner R Colin, Steele Robert J C, Wolf C Roland
Abstract excerpt
Colorectal cancer is one of the most significant causes of cancer death. A genetic model for colorectal cancer has been proposed in which the sequential accumulation of mutations in specific genes, including adenomatous polyposis coli (APC), Kirsten-ras (K-ras), and p53, drives the transition from healthy colonic epithelia through increasingly dysplastic adenoma to colorectal cancer. We have characterized tumor...
Topics
- Aged
- Aged, 80 and over
- Cohort Studies
- Colorectal Neoplasms
- Female
- Gene Frequency
- Genes, APC
- Genes, p53
- Genes, ras
- Humans
- Male