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Article

Loss of heterozygosity in human aberrant crypt foci (ACF), a putative precursor of colon cancer.

Carcinogenesis - 1 Jun 2006

Luo Liping, Shen Gong-Qing, Stiffler Karen A, Wang Qing K, Pretlow Thomas G, Pretlow Theresa P

Abstract excerpt

Aberrant crypt foci (ACF), the earliest neoplastic lesions of the colon, have genetic and epigenetic alterations. Loss of heterozygosity (LOH) of tumor suppressor gene loci is seen in most colon cancers, but it is not known how early in tumorigenesis this takes place. Nine microsatellite markers close to specific genes, that is, APC (5q21), PTPRJ (11p11), p53 (17p13) and DCC (18q21), were analyzed in 32 ACF and...

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Source

Identifiers

PMID: 16474178
DOI: 10.1093/carcin/bgi354

Genes

PTPRJ
APC
DCC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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