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Article

Concordance of Genetic Alterations in Poorly Differentiated Colorectal Neuroendocrine Carcinomas and Associated Adenocarcinomas

1 Oct 1997

Abstract excerpt

BACKGROUND: The histopathologic spectrum of colorectal neuroendocrine tumors ranges from benign to highly malignant. In this spectrum, poorly differentiated neuroendocrine carcinoma (PDNC) is the most aggressive type, characterized by early dissemination and a rapidly fatal course. Since it is unclear whether PDNC originates from neoplastic transformation of preexisting neuroectodermal cells, pluripotent...

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PMID: 9326914
DOI: 10.1093/jnci/89.19.1448

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