Article
Microsatellite alterations in adenoma and differentiated adenocarcinoma of the stomach.
Cancer research - 1 May 1995
Tamura G, Sakata K, Maesawa C, Suzuki Y, Terashima M, Satoh K, Sekiyama S, Suzuki A, Eda Y, Satodate R
Abstract excerpt
In order to elucidate the significance of the adenoma-carcinoma sequence in gastric carcinogenesis from a genetic point of view, we examined microsatellite alterations (replication error and loss of heterozygosity) on chromosomes 2p (D2S123), 3p (D3S1317), 5q (D5S409), 9p (IFNA), and 13q (D13S153) as well as p53 gene mutations in 13 adenomas and 23 differentiated adenocarcinomas including 8 early carcinomas of...
Topics
- Adenocarcinoma
- Adenoma
- Base Sequence
- DNA Replication
- DNA, Neoplasm
- DNA, Satellite
- Gene Deletion
- Genes, p53
- Heterozygote
- Humans
- Molecular Sequence Data
